Synthesis of highly efficient pH-sensitive DNA cleaving aminomethyl N-substituted cyclic enediyne and its L-lysine conjugate

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters · 1975 · 5.1K citations

Natural Sciences, Chemistry, Catalysis +11

Acid pH in tumors and its potential for therapeutic exploitation.

Ian F. Tannock, Daniela Rotin · PubMed · 1989 · 1.6K citations

Medicine, Oncology, Pharmacology +16

A Convenient Synthesis of Ethynylarenes and Diethynylarenes

S. Takahashi, Y. Kuroyama, Kenkichi Sonogashira et al. · Synthesis · 1980 · 1.1K citations

Natural Sciences, Chemistry, Organic Chemistry +5

Reactive 1,4-dehydroaromatics

Robert G. Bergman · Accounts of Chemical Research · 1973 · 754 citations

Natural Sciences, Chemistry, Analytical Chemistry +5

p-Benzyne. Generation as an intermediate in a thermal isomerization reaction and trapping evidence for the 1,4-benzenediyl structure

Richard R. Jones, Robert G. Bergman · Journal of the American Chemical Society · 1972 · 669 citations

Natural Sciences, Chemistry, Analytical Chemistry +5