Concepedia

Lysine Conjugation

Lysine Conjugation is a chemical modification method in antibody conjugation that selectively attaches payloads to lysine residues on antibodies through stable amide bond formation, distinguished from other conjugation strategies by its reliance on the nucleophilic epsilon-amino group of lysine side chains.

430

Publications

25.2K

Citations

2.2K

Authors

614

Institutions

Publications per year

2017–2026

92

Parents

Publications

430

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

Vincent Chau, John W. Tobias, Andreas Bachmair et al. · Science · 1989 · 1.5K citations

, , +14

Polycationic Peptides from Diatom Biosilica That Direct Silica Nanosphere Formation

Nils Kröger, Rainer Deutzmann, Manfred Sumper · Science · 1999 · 1.4K citations

, , +15

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

Jun Y. Axup, Krishna Bajjuri, Melissa Ritland et al. · Proceedings of the National Academy of Sciences · 2012 · 582 citations · Full text

, , +17

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Qian Zhao, Xiaohu Ouyang, Xiaobo Wan et al. · Journal of the American Chemical Society · 2017 · 376 citations

, , +15

Site‐Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase

Simone Jeger, Kurt Zimmermann, Alain Blanc et al. · Angewandte Chemie International Edition · 2010 · 330 citations

, , +17

1–5 of 430

Authors

2.2K

  1. VR
    Vishal Rai

    Indian Institute of Science Education and Research, Bhopal, India

    5 publications · 209 citations

    5

    h-index

  2. MS
    Manfred Sumper

    University of Regensburg, Germany

    5 publications · 1.8K citations

    5

    h-index

  3. SS
    Sanjeev Shukla

    Case Western Reserve University, United States

    4 publications · 196 citations

    4

    h-index

  4. KS
    Kazutaka Shimbo

    Ajinomoto (Japan), Japan

    4 publications · 209 citations

    4

    h-index

  5. IV
    Igor V. Alabugin

    Florida State University, United States

    4 publications · 152 citations

    4

    h-index

1–5 of 2.2K

Institutions

614

  1. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    66 publications

    2.9K citations

  2. National Institutes of Health

    Bethesda, United States

    10 h-index

    29 publications

    2.8K citations

  3. Scripps Research Institute

    San Diego, United States

    10 h-index

    43 publications

    5.5K citations

  4. Inserm

    Paris, France

    7 h-index

    15 publications

    758 citations

  5. National Cancer Institute

    Bethesda, United States

    7 h-index

    18 publications

    1.2K citations

  6. Harvard University

    Cambridge, United States

    7 h-index

    17 publications

    766 citations

  7. University of Utah

    Salt Lake City, United States

    6 h-index

    20 publications

    1K citations

  8. New York University

    New York, United States

    6 h-index

    9 publications

    560 citations

1–8 of 614

Venues

  1. Bioconjugate Chemistry

    47 publications · 2.2K citations

    26

    h-index

  2. Journal of Biological Chemistry

    JBC · 22 publications · 2K citations

    20

    h-index

  3. Angewandte Chemie International Edition

    13 publications · 1.2K citations

    13

    h-index

  4. Biochemistry

    12 publications · 751 citations

    12

    h-index

  5. PubMed

    Repository · 11 publications · 398 citations

    11

    h-index

1–5