Concepedia

Identification of an antimalarial synthetic trioxolane drug development candidate

Jonathan L. Vennerstrom, Sarah Arbe‐Barnes, Reto Brun, Susan A. Charman, Francis C. K. Chiu, Jacques Chollet, Yuxiang Dong, Arnulf Dorn, Daniel Hunziker, Hugues Matile,

Nature · 2004 · 617 citations · 15 references

DOI

Concepts

References

15

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

, , +16

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

, , +15

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

R. E. Desjardins, Craig J. Canfield, J. David Haynes et al. · Antimicrobial Agents and Chemotherapy · 1979 · 2.5K citations · Full text

, , +17

Artemisinins target the SERCA of Plasmodium falciparum

Ursula Eckstein‐Ludwig, Richard Webb, Iris D. A. van Goethem et al. · Nature · 2003 · 1K citations

, , +12

Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans

Katrin Palm, Patric Stenberg, Kristina Luthman et al. · Pharmaceutical Research · 1997 · 751 citations

, , +14