Concepedia

Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples

Kurt Hertogs, Stuart Bloor, Sharon D. Kemp, Christel Van den Eynde, Timothy M. Alcorn, Rudi Pauwels, Margriet Van Houtte, Schlomo Staszewski, Veronica Miller, Brendan Larder

AIDS · 2000 · 184 citations · 13 references

DOI

Abstract

Extensive use of first-generation PIs leads to the emergence of HIV-1 isolates possessing cross-resistance to all members of this class. Identification of particular mutational profiles among these isolates may assist in the design of new generation inhibitors with specific activity against protease-mutant HIV strains.

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