Concepedia

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

Rohit Kulkarni, Martin Holzenberger, David Q. Shih, Umut Özcan, Markus Stoffel, Mark A. Magnuson, C. Ronald Kahn

Nature Genetics · 2002 · 368 citations · 22 references

DOI

Concepts

References

22

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Rohit Kulkarni, Jens C. Brüning, Jonathon N. Winnay et al. · Cell · 1999 · 1.2K citations · Full text

, , +17

Induction of Pancreatic Differentiation by Signals from Blood Vessels

Eckhard Lammert, Ondine Cleaver, Douglas A. Melton · Science · 2001 · 1.1K citations

, , +17

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

Dominic J. Withers, Deborah J. Burks, Heather Towery et al. · Nature Genetics · 1999 · 527 citations

, , +12

Regulation of a Transcription Factor Network Required for Differentiation and Metabolism

Stephen A. Duncan, María‐Ángeles Navas, Daniel Dufort et al. · Science · 1998 · 342 citations

, , +10

Exocytosis of Insulin Promotes Insulin Gene Transcription via the Insulin Receptor/PI-3 Kinase/p70 s6 Kinase and CaM Kinase Pathways

Ingo B. Leibiger, Barbara Leibiger, Tilo Moede et al. · Molecular Cell · 1998 · 283 citations · Full text

, , +16