Concepedia

Association Between Genetic Variants in the<i>IL</i>-<i>23R</i>Gene and Early-Onset Crohn's Disease: Results From a Case-Control and Family-Based Study Among Canadian Children

Devendra Amre, David R. Mack, David M. Israel, Kenneth Morgan, Philippe Lambrette, Liliane Law, Guy Grimard, Colette Deslandres, Alfreda Krupoves, Vytautas Bucionis,

The American Journal of Gastroenterology · 2008 · 65 citations · 21 references

DOI

Abstract

Our findings confirm recently reported genome-wide associations between the IL-23R gene and CD. They suggest that the gene is also associated with pediatric-onset CD among Canadian children.

References

21

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.8K citations

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Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan et al. · Nature Immunology · 2005 · 4.6K citations

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Claire L. Langrish, Yi Chen, Wendy M. Blumenschein et al. · The Journal of Experimental Medicine · 2005 · 4K citations · Full text

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

Richard S. Spielman, Ralph McGinnis, Warren J. Ewens · PubMed · 1993 · 3.7K citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Marc Veldhoen, Richard J. Hocking, Christopher J. Atkins et al. · Immunity · 2006 · 3.6K citations · Full text

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