Concepedia

Efficacy and Safety of Inhaled Carbon Monoxide during Pulmonary Inflammation in Mice

Michael R. Wilson, Kieran P. O’Dea, Anthony D. Dorr, Hirotoshi Yamamoto, Michael E. Goddard, Masao Takata

PLoS ONE · 2010 · 29 citations · 33 references

DOIFull text

Open access

Abstract

Overall, these data confirm some protective role for inhaled CO during pulmonary inflammation, although this required a dose that produced carboxyhemoglobin values close to potentially toxic levels for humans, and increased lung permeability.

References

33

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

Leo E. Otterbein, Fritz H. Bach, Jawed Alam et al. · Nature Medicine · 2000 · 2.1K citations

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Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis

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Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

Kiichi Nakahira, Hong Pyo Kim, Xue Geng et al. · The Journal of Experimental Medicine · 2006 · 351 citations · Full text

Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury

Jörg Reutershan, Abdul Basit, Elena Galkina et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2005 · 310 citations