Synthesis and evaluation of ligands for D2-like receptors: The role of common pharmacophoric groups

Antipsychotic drug doses and neuroleptic/dopamine receptors

Philip Seeman, T. Lee, M. Chau-Wong et al. · Nature · 1976 · 1.6K citations

Medicine, Pharmacology, Psychiatry +13

Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

Sean M Renock, Elaine G. Arrington, Louis A. Chiodo et al. · Neuropsychopharmacology · 2003 · 974 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +10

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

Philip Seeman, Teresa Lee · Science · 1975 · 869 citations

Medicine, Neuroscience, Pharmacology +13

3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D₄ Receptor

Janusz J. Kulagowski, Howard B. Broughton, Neil R. Curtis et al. · Journal of Medicinal Chemistry · 1996 · 257 citations · Full text

Medicine, Pharmacology, Neurochemistry +4

The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder

María Elena Avale, Tomás L. Falzone, Diego M. Gelman et al. · Molecular Psychiatry · 2003 · 150 citations · Full text

Medicine, Neurobiology, Neuroscience +16