Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +9

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

David Lando, Daniel J. Peet, Dean A. Whelan et al. · Science · 2002 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +14

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Edurne Berra · The EMBO Journal · 2003 · 1.3K citations · Full text

Life Sciences, Biochemistry, Physiology +13

Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

Rebecca J. Appelhoff, Ya‐Min Tian, Raju R. Raval et al. · Journal of Biological Chemistry · 2004 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor

Maija Hirsilä, Peppi Koivunen, Volkmar Günzler et al. · Journal of Biological Chemistry · 2003 · 789 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12