Comparative thermodynamic study of the interaction of some antifolates with dihydrofolate reductase

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.

J.T. Bolin, David J. Filman, David A. Matthews et al. · Journal of Biological Chemistry · 1982 · 745 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

David A. Matthews, J.T. Bolin, Jane M. Burridge et al. · Journal of Biological Chemistry · 1985 · 272 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

Terence R. Jones, A H Calvert, Ann L. Jackman et al. · European Journal of Cancer (1965) · 1981 · 239 citations

Life Sciences, Medicinal Chemistry, Pharmacology +7

Inhibition of dihydrofolate reductase: effect of NADPH on the selectivity and affinity of diaminobenzylpyrimidines

David P. Baccanari, Susan M. Daluge, R. W. King · Biochemistry · 1982 · 100 citations

Life Sciences, Biochemistry, Pharmacology +10

Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase

Kazunari Taira, Stephen J. Benkovic · Journal of Medicinal Chemistry · 1988 · 95 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17