Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

Yuesheng Zhang, Paul Talalay, C G Cho et al. · Proceedings of the National Academy of Sciences · 1992 · 1.7K citations

Life Sciences, Biochemistry, Toxicology +16

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

Takafumi Suzuki, Akira Kobayashi, Junko Wakabayashi et al. · Molecular and Cellular Biology · 2008 · 501 citations

Life Sciences, Biochemistry, Molecular Biology +14

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

Shinsuke Homma, Yukio Ishii, Yuko Morishima et al. · Clinical Cancer Research · 2009 · 417 citations

Medicine, Oncology, Pharmacology +14

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

Sanjit K. Roy, Rakesh K. Srivastava, Sharmila Shankar · Journal of Molecular Signaling · 2010 · 376 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Sulforaphane-induced Cell Death in Human Prostate Cancer Cells Is Initiated by Reactive Oxygen Species

Shivendra V. Singh, Sanjay Srivastava, Sunga Choi et al. · Journal of Biological Chemistry · 2005 · 367 citations · Full text

Life Sciences, Cell Biology, Pharmacology +17