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Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site

Medicinal ChemistryAvailable Mmp-13 InhibitorsBiochemistryCarboxybenzene GroupMedicineNatural SciencesRational Drug DesignS1″ Binding SitePharmacological AgentPharmacotherapyDrug DevelopmentPharmacologyPharmaceutical ChemistryDrug Discovery