Concepedia

Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/BclXL-regulated mitochondrial apoptotic pathway

Ke‐Wu Zeng, Xuemei Wang, Hyeonseok Ko, Hak Cheol Kwon, Jin Wook, Hyun Ok Yang

European Journal of Pharmacology · 2011 · 149 citations · 34 references

DOI

Concepts

References

34

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Anne Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell · 1999 · 6.6K citations · Full text

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Sandeep Robert Datta, Henryk Dudek, Xu Tao et al. · Cell · 1997 · 5.7K citations · Full text

, , +16

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

Luis del Peso, Maribel González-Garcı́a, Carmen Page et al. · Science · 1997 · 2.2K citations

, , +17

Mitochondrial Abnormalities in Alzheimer's Disease

Keisuke Hirai, Gjumrakch Aliev, Akihiko Nunomura et al. · Journal of Neuroscience · 2001 · 1.4K citations · Full text

, , +14

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

P. Hemachandra Reddy, M. Flint Beal · Trends in Molecular Medicine · 2008 · 970 citations · Full text

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