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An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein–Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness

ImmunodeficienciesImmunologyTumor ImmunityImmunodominanceImmune RegulationImmune SurveillanceAge-related IncreaseT Cell ImmunityCd4 T Cell ResponsesHumoral ImmunityCd8+ T CellsCellular Immune ResponseChronic Viral InfectionImmune SystemMedicineViral ImmunityAntigen-specific Responsiveness