HETEROTRANSPLANTATION OF HUMAN EPIDERMOID CARCINOMAS TO THE MOUSE MUTANT <i>NUDE</i>

Abstract

Successful heterotransplantation is reported for 3 out of 4 human epidermoid carcinomas, consecutively transplanted to the mouse mutant nude. Serial transmission was obtained in two cases, so far for 2–5 passages. Tumours grew locally in mice, and no metastases were observed. Histological and cytological appearance of the grafts were in full accord with the original human tumour. The mouse mutant nude is suggested as a host for human epidermoid carcinomas in the study of oncostatic agents.