Concepedia

Activation of Matrix Metalloproteinases Precedes Left Ventricular Remodeling in Hypertensive Heart Failure Rats

Yasushi Sakata, Kazuhiro Yamamoto, Toshiaki Mano, Nagahiro Nishikawa, Junichi Yoshida, Masatsugu Hori, Takeshi Miwa, Tohru Masuyama

Circulation · 2004 · 175 citations · 26 references

DOI

Abstract

MMPs are likely to trigger and promote LV remodeling, and ACE inhibition directly exerts inhibitory effect on MMPs, leading to the prevention of LV remodeling and dysfunction.

References

26

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

Zorina S. Galis, Galina K. Sukhova, Michael W. Lark et al. · Journal of Clinical Investigation · 1994 · 2.5K citations · Full text

Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms

G. Matthew Longo, Wanfen Xiong, Timothy C. Greiner et al. · Journal of Clinical Investigation · 2002 · 982 citations · Full text

Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms

G. Matthew Longo, Wanfen Xiong, Timothy C. Greiner et al. · Journal of Clinical Investigation · 2002 · 869 citations

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Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

Anique Ducharme, Stefan Frantz, Masanori Aikawa et al. · Journal of Clinical Investigation · 2000 · 805 citations · Full text

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A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure

Francis G. Spinale, Mytsi L. Coker, Lena J. Heung et al. · Circulation · 2000 · 475 citations