Generation of mutant mice lacking surfaceexpression of CD4 or CD8 by gene targeting

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Life Sciences, Developmental Biology, Molecular Biology +12

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

Paweł Kisielow, Horst Blüthmann, Uwe D. Staerz et al. · Nature · 1988 · 1.7K citations

Life Sciences, Cell Biology, Immunology +14

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

Yusuke Yanagi, Yasunobu Yoshikai, Kathleen Leggett et al. · Nature · 1984 · 1.3K citations

Life Sciences, Immunology, Molecular Biology +11

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

Stephen Μ. Hedrick, David I. Cohen, Ellen A. Nielsen et al. · Nature · 1984 · 1.2K citations

Life Sciences, Immunology, Molecular Biology +12

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

Oliver Smithies, Ronald G. Gregg, Sallie S. Boggs et al. · Nature · 1985 · 995 citations

Medicine, Genetics, Molecular Genetics +7