Publication | Closed Access

Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases

Medicinal ChemistryBioorganic ChemistryBiochemistryMedicineNatural SciencesGlycobiologyβ-Galactosidases Whereas L-dmdpCarbohydrate-protein InteractionDrug DevelopmentGlass InhibitorsPharmacologyScalable SynthesesPharmaceutical ChemistryInhibitory ActivityDrug DiscoveryGlycosylation