Saori Miyauchi

α-1-<i>C</i>-Butyl-1,4-dideoxy-1,4-imino-<scp>l</scp>-arabinitol as a Second-Generation Iminosugar-Based Oral α-Glucosidase Inhibitor for Improving Postprandial Hyperglycemia

Atsushi Kato, Erina Hayashi, Saori Miyauchi et al. · Journal of Medicinal Chemistry · 2012 · 79 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases

Daniel Best, Chen Wang, Alexander C. Weymouth‐Wilson et al. · Tetrahedron Asymmetry · 2010 · 54 citations

Life Sciences, Biochemistry, Medicinal Chemistry +7

Looking glass inhibitors: both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-d-lyxitol [a potent competitive inhibitor of α-d-galactosidase] and of 1,4-dideoxy-1,4-imino-l-lyxitol [a weak competitive inhibitor of α-d-galactosidase] inhibit naringinase, an α-l-rhamnosidase competitively

Thomas B. Mercer, Sarah F. Jenkinson, Barbara Bartholomew et al. · Tetrahedron Asymmetry · 2009 · 43 citations

Life Sciences, Biochemistry, Medicinal Chemistry +11

Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of <i>N</i>‐Alkylation on Hexosaminidase Inhibition

Andreas F. G. Glawar, Daniel Best, Benjamin James Ayers et al. · Chemistry - A European Journal · 2012 · 42 citations

Life Sciences, Biochemistry, Medicinal Chemistry +12

Synthesis of both enantiomers of hydroxypipecolic acid derivatives equivalent to 5-azapyranuronic acids and evaluation of their inhibitory activities against glycosidases

Yuichi Yoshimura, Chiaki Ohara, Tatsushi Imahori et al. · Bioorganic & Medicinal Chemistry · 2008 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10