Robert A. Clarkson

Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases

Daniel Best, Chen Wang, Alexander C. Weymouth‐Wilson et al. · Tetrahedron Asymmetry · 2010 · 54 citations

Life Sciences, Biochemistry, Medicinal Chemistry +7

Large scale synthesis of the acetonides of l-glucuronolactone and of l-glucose: easy access to l-sugar chirons

Alexander C. Weymouth‐Wilson, Robert A. Clarkson, Nigel A. Jones et al. · Tetrahedron Letters · 2009 · 28 citations

Pharmacy, Biochemistry, Chemistry +11

Carbon-branched carbohydrate chirons: practical access to both enantiomers of 2-C-methyl-ribono-1,4-lactone and 2-C-methyl-arabinonolactone

K.V. Booth, Filipa P. da Cruz, David J. Hotchkiss et al. · Tetrahedron Asymmetry · 2008 · 22 citations

Pharmacy, Biochemistry, Chemistry +8