Identification of the major urinary metabolites of 6-ketoprostaglandin F1α (6K-PGF1α) in the rat

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

Ryszard J. Gryglewski, Stuart Bunting, Salvador Moncada et al. · Prostaglandins · 1976 · 1K citations

Medicine, Cardiology, Hematology +13

The chemical structure of prostaglandin X (prostacyclin)

Roy A. Johnson, Douglas R. Morton, John H. Kinner et al. · Prostaglandins · 1976 · 730 citations

Natural Sciences, Chemistry, Pharmacology +10

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

C.R. Pace-Asciak, L. S. Wolfe · Biochemistry · 1971 · 162 citations

Medicine, Biochemistry, Pharmacology +13

Distribution of prostaglandin biosynthetic pathways in several rat tissues. Formation of 6-ketoprostaglandin F1α

C.R. Pace-Asciak, Godha Rangaraj · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1977 · 127 citations

Life Sciences, Biochemistry, Pharmacology +11