p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

Pavel G. Komarov, Elena A. Komarova, Roman V. Kondratov et al. · Science · 1999 · 1.3K citations

Cancer Therapy, Chemoprevention Strategy, Apoptosis +17

The coordinate regulation of the p53 and mTOR pathways in cells

Zhaohui Feng, Haiyan Zhang, Arnold J. Levine · Proceedings of the National Academy of Sciences · 2005 · 1.2K citations · Full text

Mitophagy, Molecular Biology, Cell Death +21

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

Tong Cheng, Dong Liu, John H. Griffin et al. · Nature Medicine · 2003 · 559 citations

Glioma, Medicine, Protein C +11

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide

Carsten Culmsee, Xiaoxiang Zhu, Qian‐sheng Yu et al. · Journal of Neurochemistry · 2001 · 316 citations

Chemoprevention Strategy, Mitochondrial Dysfunction, Apoptosis +16

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

R. Christian Crumrine, Amy L. Thomas, Philip F. Morgan · Journal of Cerebral Blood Flow & Metabolism · 1994 · 314 citations · Full text

Apoptosis, Cell Death, Cerebrovascular Disease +22