Journal of Medicinal Chemistry · 1998 · 217 citations · 12 references
PharmacyMedicinal ChemistryPharmacologyMolecular VirologySynthetic Medicinal ChemistryVirologyAntiviral AgentsAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyViral InfectionsAntiviral Drug DesignAntiviral Structure-activity RelationshipsCytomegalovirus DiseasePyridine ChemistryPyridine SynthesisStereochemical Structure - Activity RelationshipTherapeutic Index DeterminationVaricella-zoster Virus Infections
The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.
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Suppression of mouse viraemia and retroviral disease by 3′-azido-3′-deoxythymidine
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