A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study

Daniel J. Drucker, John B. Buse, Kristin Taylor et al. · The Lancet · 2008 · 1.1K citations

Medicine, Endocrinology, Pharmacotherapy +12

A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis

Laurie L. Baggio, Qingling Huang, Theodore J. Brown et al. · Diabetes · 2004 · 379 citations · Full text

Life Sciences, Endocrinology, Pharmacology +17

Antibodies against Polyethylene Glycol Produced in Animals by Immunization with Monomethoxy Polyethylene Glycol Modified Proteins

Ary Wolfgang Richter, Eva Åkerblom · International Archives of Allergy and Applied Immunology · 2009 · 282 citations

Life Sciences, Immunology, Allergy +16

Site-specific PEGylation of native disulfide bonds in therapeutic proteins

Sunil Shaunak, Antony Godwin, Ji-Won Choi et al. · Nature Chemical Biology · 2006 · 258 citations

Life Sciences, Biochemistry, Pharmaceutics +16

Short Communication: Renal Tubular Vacuolation in Animals Treated with Polyethylene-Glycol-Conjugated Proteins

Alison M. Bendele, Jim Seely, Carl Richey et al. · Toxicological Sciences · 1998 · 248 citations · Full text

Medicine, Nephrology, Pathobiology +17