Canine intestinal mast cell tumor with c-kit exon 8 mutation responsive to imatinib therapy

Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation

Cristina R. Antonescu, Peter Besmer, Tianhua Guo et al. · Clinical Cancer Research · 2005 · 831 citations

Medicine, Molecular Medicine, Oncology +15

Pharmacokinetics and Pharmacodynamics of Imatinib in a Phase I Trial With Chronic Myeloid Leukemia Patients

Bin Peng, Michael Hayes, Debra Resta et al. · Journal of Clinical Oncology · 2004 · 470 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +13

Gain-of-Function Mutations in the Extracellular Domain of KIT Are Common in Canine Mast Cell Tumors

Sébastien Letard, Ying Yang, Katia Hanssens et al. · Molecular Cancer Research · 2008 · 184 citations

Medicine, Molecular Genetics, Oncology +17

Neoplasia Driven by Mutant c-<i>KIT</i> Is Mediated by Intracellular, Not Plasma Membrane, Receptor Signaling

Zhifu Xiang, Frederike Kreisel, Jennifer Cain et al. · Molecular and Cellular Biology · 2006 · 117 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Effect of Tyrosine Kinase Inhibition by Imatinib Mesylate on Mast Cell Tumors in Dogs

Mayu Isotani, Nobuhiro Ishida, M. Tominaga et al. · Journal of Veterinary Internal Medicine · 2008 · 106 citations · Full text

Medicine, Immunology, Oncology +15