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Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Cheng Hua Jin, Maddeboina Krishnaiah, D. Sreenu, Kota Sudhakar Rao, Vura Bala Subrahmanyam, Chul‐Yong Park, Jee‐Yeon Son, Yhun Yhong Sheen, Dae‐Kee Kim

Bioorganic & Medicinal Chemistry · 2011 · 32 citations · 28 references

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28

TGFβ signals through a heteromeric protein kinase receptor complex

Jeffrey L. Wrana, Liliana Attisano, Juan M. Cárcamo et al. · Cell · 1992 · 1.5K citations

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SB-505124 Is a Selective Inhibitor of Transforming Growth Factor-β Type I Receptors ALK4, ALK5, and ALK7

Stacey DaCosta Byfield, Christopher Major, Nicholas J. Laping et al. · Molecular Pharmacology · 2004 · 416 citations

, , +13

The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β

Masayoshi Tojo, Yoshio Hamashima, Aki Hanyu et al. · Cancer Science · 2005 · 354 citations · Full text

, , +16

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

Patrick A. Eyers, Molly Craxton, Nick Morricel et al. · Chemistry & Biology · 1998 · 315 citations · Full text

, , +8

A Specific Inhibitor of TGF-β Receptor Kinase, SB-431542, as a Potent Antitumor Agent for Human Cancers

Sunil K. Halder, R. Daniel Beauchamp, Pran K. Datta · Neoplasia · 2005 · 286 citations · Full text

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