A Specific Inhibitor of TGF-β Receptor Kinase, SB-431542, as a Potent Antitumor Agent for Human Cancers

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

Gareth J. Inman, Francisco José Nicolás, James F. Callahan et al. · Molecular Pharmacology · 2002 · 1.6K citations

Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

Neil A. Bhowmick, Mayshan Ghiassi, Andrei V. Bakin et al. · Molecular Biology of the Cell · 2001 · 989 citations · Full text

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

Gillian S. Ashcroft, Xiao Yang, Adam B. Glick et al. · Nature Cell Biology · 1999 · 909 citations

Inflammation, Cytokine, Immunology +10

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

Arnold E. Postlethwaite, Jorma Keski‐Oja, Harold L. Moses et al. · The Journal of Experimental Medicine · 1987 · 780 citations · Full text

Epidermal Growth Factor, Chemotactic Migration, Immunology +17

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

Nicholas J. Laping, Eugene T. Grygielko, Anil Mathur et al. · Molecular Pharmacology · 2002 · 647 citations