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Proteasome Regulator Marizomib (NPI-0052) Exhibits Prolonged Inhibition, Attenuated Efflux, and Greater Cytotoxicity than Its Reversible Analogs

Amanda Obaidat, Jeffrey Weiss, Brett Wahlgren, Rama Rao Manam, Venkat R. Macherla, Katherine McArthur, Ta‐Hsiang Chao, Michael A. Palladino, G. Kenneth Lloyd, Barbara C. M. Potts,

Journal of Pharmacology and Experimental Therapeutics · 2011 · 32 citations · 17 references

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17

Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus <i>Salinospora</i>

Robert H. Feling, Greg O. Buchanan, Tracy J. Mincer et al. · Angewandte Chemie International Edition · 2003 · 1.1K citations · Full text

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Dharminder Chauhan, Laurence Catley, Guilan Li et al. · Cancer Cell · 2005 · 698 citations · Full text

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Bortezomib for the Treatment of Mantle Cell Lymphoma

Robert C. Kane, Ramzi Dagher, Ann T. Farrell et al. · Clinical Cancer Research · 2007 · 333 citations · Full text

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Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding

M. Groll, Robert Huber, Barbara C. M. Potts · Journal of the American Chemical Society · 2006 · 314 citations

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Venkat R. Macherla, Scott S. Mitchell, Rama Rao Manam et al. · Journal of Medicinal Chemistry · 2005 · 235 citations

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