Rama Rao Manam

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Venkat R. Macherla, Scott S. Mitchell, Rama Rao Manam et al. · Journal of Medicinal Chemistry · 2005 · 235 citations

Proteasome Inhibition, Medicinal Chemistry, Pharmaceutical Chemistry +14

Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete <i>Streptomyces </i><i>n</i><i>odosus</i>

Rama Rao Manam, Sy Teisan, Donald J White et al. · Journal of Natural Products · 2005 · 131 citations

Bioorganic Chemistry, Scripps Canyon, Antimicrobial Chemotherapy +16

Salinosporamides D−J from the Marine Actinomycete <i>Salinispora tropica</i>, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Katherine A. Reed, Rama Rao Manam, Scott S. Mitchell et al. · Journal of Natural Products · 2007 · 87 citations

Salinosporamides F, Medicinal Chemistry, Marine Biotechnology +15

Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

Taotao Ling, Venkat R. Macherla, Rama Rao Manam et al. · Organic Letters · 2007 · 86 citations

Medicinal Chemistry, Chiral Centers, Bioorganic Chemistry +15

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Rama Rao Manam, Katherine McArthur, Ta‐Hsiang Chao et al. · Journal of Medicinal Chemistry · 2008 · 53 citations

Chemoprevention Strategy, Proteasome, Pharmacotherapy +16