Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 886 citations

Life Sciences, Medicinal Chemistry, Pharmacology +14

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Simone Fulda, Claudia Friesen, Carsten Scaffidi et al. · PubMed · 1997 · 348 citations · Full text

Life Sciences, Cell Biology, Oncology +17

The cytotoxic activity of ursolic acid derivatives

Chao‐Mei Ma, Shao‐Qing Cai, Jingrong Cui et al. · European Journal of Medicinal Chemistry · 2005 · 233 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells

Ya‐Ling Hsu, Po‐Lin Kuo, Chun‐Ching Lin · Life Sciences · 2004 · 219 citations

Medicine, Oncology, Pharmacology +16

Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15

Jie Li · World Journal of Gastroenterology · 2002 · 214 citations · Full text

Medicine, Oncology, Pharmacology +11