The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1)

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Monoclonal Antibody Mrk16, Cellular Localization, Immunology +18

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Oral Bioavailability, Immunology, Pharmacotherapy +17

Choroid plexus epithelial expression of <i>MDR</i> <i>1</i> P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

V. Venkat Rao, Julie L. Dahlheimer, Mark E. Bardgett et al. · Proceedings of the National Academy of Sciences · 1999 · 525 citations · Full text

Cellular Pharmacology, Cellular Physiology, Drug Resistance +16

HIV-1 Protease Inhibitors Are Substrates for the<i>MDR</i>1 Multidrug Transporter

Caroline Lee, Michael M. Gottesman, Carol Cardarelli et al. · Biochemistry · 1998 · 481 citations

Protease Inhibitors, Biochemistry, Medicine +14

Tissue distribution of the multidrug resistance protein.

M J Flens, G J Zaman, Paul van der Valk et al. · PubMed · 1996 · 477 citations