A transgenic Neospora caninum strain based on mutations of the dihydrofolate reductase-thymidylate synthase gene

Genetic regulatory mechanisms in the synthesis of proteins

François Jacob, Jacques Monod · Journal of Molecular Biology · 1961 · 6.5K citations

Transcriptional Regulation, Protein Expression, Protein Biosynthesis +7

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

David S. Peterson, David Walliker, Thomas E. Wellems · Proceedings of the National Academy of Sciences · 1988 · 650 citations · Full text

Point Mutations, Biochemistry, Falciparum Malaria +13

High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei

Chris J. Janse, Jai Ramesar, Andrew P. Waters · Nature Protocols · 2006 · 645 citations

Drug Selection, Blood Stages, Medicine +9

Tagging of Endogenous Genes in a <i>Toxoplasma gondii</i> Strain Lacking Ku80

My‐Hang Huynh, Vern B. Carruthers · Eukaryotic Cell · 2009 · 536 citations · Full text

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

Alan F. Cowman, M J Morry, Beverley‐Ann Biggs et al. · Proceedings of the National Academy of Sciences · 1988 · 509 citations · Full text

Biosynthesis, Plasmodium Falciparum, Drug Resistance Analysis +15