Concepedia

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents

Robert J. Cherney, Ruowei Mo, Dayton T. Meyer, Li Wang, Wenqing Yao, Zelda R. Wasserman, Rui‐Qin Liu, Maryanne Covington, Micky D. Tortorella, Elizabeth C. Arner,

Bioorganic & Medicinal Chemistry Letters · 2003 · 38 citations · 13 references

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13

Asymmetric alkylation reactions of chiral imide enolates. A practical approach to the enantioselective synthesis of .alpha.-substituted carboxylic acid derivatives

David A. Evans, Michael D. Ennis, David J. Mathre · Journal of the American Chemical Society · 1982 · 1K citations

, , +11

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

Ilgar Abbaszade, Rui‐Qin Liu, Fude Yang et al. · Journal of Biological Chemistry · 1999 · 489 citations · Full text

, , +17

The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

Stefan Lohmander, Peter J. Neame, John D. Sandy · Arthritis & Rheumatism · 1993 · 437 citations

, , +17

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

John D. Sandy, Carl R. Flannery, Peter J. Neame et al. · Journal of Clinical Investigation · 1992 · 416 citations · Full text

, , +16

Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits

Lawrence MacPherson, Erol K. Bayburt, Michael Capparelli et al. · Journal of Medicinal Chemistry · 1997 · 325 citations · Full text

, , +15