Designing Thermostable Proteins: Ancestral Mutants of 3-Isopropylmalate Dehydrogenase Designed by using a Phylogenetic Tree

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

Naruya Saitou, M Nei · Molecular Biology and Evolution · 1987 · 60.5K citations · Full text

Life Sciences, Bioinformatics, Evolutionary Biology +17

Evolutionary trees from DNA sequences: A maximum likelihood approach

Joseph Felsenstein · Journal of Molecular Evolution · 1981 · 14.9K citations

Life Sciences, Bioinformatics, Evolutionary Biology +14

Bacterial evolution.

C R Woese · Microbiological Reviews · 1987 · 2.5K citations

Directed evolution of a thermostable esterase

Lori Giver, Anne Gershenson, Per‐Ola Freskgård et al. · Proceedings of the National Academy of Sciences · 1998 · 530 citations

Life Sciences, Biochemistry, Molecular Biology +17

The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures

KSP Yip, TJ Stillman, K.L. Britton et al. · Structure · 1995 · 411 citations · Full text

Life Sciences, Biochemistry, Microbiology +17