An Experimental Model for the Study of Lymphedema and its Response to Therapeutic Lymphangiogenesis

A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases.

Vladimir Joukov, Katri Pajusola, Arja Kaipainen et al. · The EMBO Journal · 1996 · 1.7K citations · Full text

Life Sciences, Cell Biology, Pharmacology +11

LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan

Suneale Banerji, Jian Ni, Shuxia Wang et al. · The Journal of Cell Biology · 1999 · 1.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

Michael Jeltsch, Arja Kaipainen, Vladimir Joukov et al. · Science · 1997 · 1.3K citations · Full text

Medicine, Immunology, Oncology +17

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

Taija Mäkinen, Lotta Jussila, Tanja Veikkola et al. · Nature Medicine · 2001 · 780 citations

Medicine, Developmental Biology, Molecular Medicine +13

A model for gene therapy of human hereditary lymphedema

Marika J. Karkkainen, Anne Saaristo, Lotta Jussila et al. · Proceedings of the National Academy of Sciences · 2001 · 611 citations · Full text

Medicine, Genetics, Molecular Genetics +17