Chemical Communications · 2013 · 46 citations · 21 references
Life SciencesBiochemistryNeuroscienceMolecular NeuroscienceNeurodegenerationPost-translational ModificationNeurodegenerative DiseasesNeurodegenerative DisordersParkinson DiseaseProtein SynthesisProtein TargetingSynaptic TransmissionAlpha-synuclein AggregationAlpha-synuclein MisfoldingParkinson Disease PathologyPathogenic Effects
Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.
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Synthesis of Proteins by Native Chemical Ligation
Philip E. Dawson, Tom W. Muir, Ian Clark‐Lewis et al. · Science · 1994 · 4.1K citations
NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded
Paul H. Weinreb, Weiguo Zhen, Anna W. Poon et al. · Biochemistry · 1996 · 1.5K citations