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Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate

Yun W. Alelyunas, James R. Empfield, Dennis J. McCarthy, Russell C. Spreen, Khanh Bui, Luciana Pelosi-Kilby, Cindy Shen

Bioorganic & Medicinal Chemistry Letters · 2010 · 60 citations · 24 references

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24

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes, Julian Blagg, David A. Price et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 973 citations

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The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 407 citations

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Assessment of Melamine and Cyanuric Acid Toxicity in Cats

Birgit Puschner, Robert H. Poppenga, Linda J. Lowenstine et al. · Journal of Veterinary Diagnostic Investigation · 2007 · 382 citations · Full text

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Estimation of the aqueous solubility I: Application to organic nonelectrolytes

Neera Jain, Samuel H. Yalkowsky · Journal of Pharmaceutical Sciences · 2001 · 367 citations · Full text

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Time-Related Differences in the Physical Property Profiles of Oral Drugs

Paul D. Leeson, A. M. Davis · Journal of Medicinal Chemistry · 2004 · 325 citations

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