Arthritis & Rheumatism · 1991 · 31 citations · 38 references
Life SciencesCell BiologyImmunologyAutoimmunityCellular ImmunologyInflammationAutoimmune DiseasesImmune Cell SignalingLymphocyte ActivationSystemic Lupus ErythematosusT Cell ActivationT Cell BiologyAntigen-induced Lymphocyte ProliferationCd3 Complex SignalingCell ActivationCytokine Receptor ExpressionLectinsT Cell-mediated Immune ResponseT-cell Mediated Immune ResponseT-cell Mediated Responses
Nonfractionated peripheral blood lymphocytes from patients with systemic lupus erythematosus (SLE) showed enhanced proliferative responses when stimulated via the CD3 pathway. In contrast, proliferative responses induced by phytohemagglutinin were diminished in SLE patients. Levels of CD3-induced interleukin-2 production and interleukin-2 receptor expression were comparable with normal levels. Highly purified T cells also showed augmented CD3 responses, but only in the presence of phorbol myristate acetate or a combination of phorbol myristate acetate plus calcium ionophore A23187, and not with calcium ionophore alone. The data suggest integrity of the T cell receptor/CD3 pathway for T cell activation in patients with SLE, as examined in cultures stimulated with specific anti-CD3 monoclonal antibodies rather than with multivalent lectins. An increased response via the CD3 complex could contribute to the autoimmune activity in human SLE.
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan, Alan S. Cohen, James F. Fries et al. · Arthritis & Rheumatism · 1982 · 14.6K citations