A genetically modified recombinant tumor necrosis factor-α conjugated to the distal terminals of liposomal surface grafted polyethyleneglycol chains

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

James Carmichael, William DeGraff, Adi F. Gazdar et al. · PubMed · 1987 · 3.8K citations

Medicine, Pharmacology, Chemotherapy +11

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

Bruce Beutler, Ian W. Milsark, Anthony Cerami · The Journal of Immunology · 1985 · 769 citations

Life Sciences, Endocrinology, Pharmacokinetics +10

Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target

A.L. Klibanov, Kazuo Maruyama, Anne Marie Beckerleg et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1991 · 483 citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17

Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity

Vladimir P. Torchilin, Vladimir G. Omelyanenko, Mikhail Papisov et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1994 · 465 citations

Natural Sciences, Biochemistry, Biomedical Engineering +16

Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times

Gabriele Blume, Gregor Cevc, M.D.J.A. Crommelin et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1993 · 281 citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +16