Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

Shaomin Li, Soyon Hong, Nina E. Shepardson et al. · Neuron · 2009 · 935 citations · Full text

Synaptic Plasticity, Molecular Neuroscience, Psychiatry +10

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

Harry F. Dovey, Varghese John, J. P. Anderson et al. · Journal of Neurochemistry · 2001 · 877 citations · Full text

Protein Secretion, Neurochemical Biomarkers, Amyloid Precursor Protein +17

γ-Secretase inhibitors repress thymocyte development

Brandon Hadland, Nancy R. Manley, Dongming Su et al. · Proceedings of the National Academy of Sciences · 2001 · 185 citations · Full text

Lymphocyte Development, Immunology, Immune Regulation +17

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Kevin W. Gillman, John E. Starrett, Michael F. Parker et al. · ACS Medicinal Chemistry Letters · 2010 · 183 citations

Pharmaceutical Science, Pharmacotherapy, Pharmaceutical Chemistry +19

Dynamics of β-Amyloid Reductions in Brain, Cerebrospinal Fluid, and Plasma of β-Amyloid Precursor Protein Transgenic Mice Treated with a γ-Secretase Inhibitor

Donna M. Barten, Valerie Guss, Jason A. Corsa et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 159 citations