Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease

References

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	Year	Citations
Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake Shaomin Li, Soyon Hong, Nina E. Shepardson, Neuron Synaptic PlasticityMolecular NeurosciencePsychiatrySynaptic TransmissionSoluble Oligomers	2009	935
Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain Harry F. Dovey, Varghese John, J. P. Anderson, Journal of Neurochemistry Protein SecretionNeurochemical BiomarkersAmyloid Precursor ProteinSocial SciencesAlzheimer's Disease	2001	877
γ-Secretase inhibitors repress thymocyte development Brandon Hadland, Nancy R. Manley, Dongming Su, Proceedings of the National Academy of Sciences Lymphocyte DevelopmentImmunologyImmune RegulationAβ42 PeptidesImmunologic Mechanism	2001	185
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor Kevin W. Gillman, John E. Starrett, Michael F. Parker, ACS Medicinal Chemistry Letters Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryMedicinal ChemistryAlzheimer's Disease	2010	183
Dynamics of β-Amyloid Reductions in Brain, Cerebrospinal Fluid, and Plasma of β-Amyloid Precursor Protein Transgenic Mice Treated with a γ-Secretase Inhibitor Donna M. Barten, Valerie Guss, Jason A. Corsa, Journal of Pharmacology and Experimental Therapeutics	2005	159
Safety, Tolerability, and Effects on Plasma and Cerebrospinal Fluid Amyloid-β After Inhibition of γ-Secretase Eric Siemers, Robert A. Dean, Stuart Friedrich, Clinical Neuropharmacology	2007	153
Concentration-Dependent Modulation of Amyloid-β in Vivo and in Vitro Using the γ-Secretase Inhibitor, LY-450139 Thomas A. Lanz, Michael J. Karmilowicz, Kathleen M. Wood, Journal of Pharmacology and Experimental Therapeutics	2006	133
Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease Scott C. Mayer, Anthony F. Kreft, Boyd L. Harrison, Journal of Medicinal Chemistry Stable Analogue 10Alzheimer ’Social SciencesNeuroinflammationAlzheimer's Disease	2008	109
Pharmacodynamics and Pharmacokinetics of the γ-Secretase Inhibitor PF-3084014 Thomas A. Lanz, Kathleen M. Wood, K. Richter, Journal of Pharmacology and Experimental Therapeutics	2010	50
Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease Christopher J. Helal, Zhijun Kang, John C. Lucas, Bioorganic & Medicinal Chemistry Letters Molecular PharmacologyDrug TargetAlzheimer's DiseaseBiochemistryActive 4-Aminoimidazole Inhibitors	2009	47

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