Anesthesia Leads to Tau Hyperphosphorylation through Inhibition of Phosphatase Activity by Hypothermia

Emmanuel Planel, K. Richter, Charles E. Nolan, +10

Journal of Neuroscience

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

Romain Rouet, Benjamin A. Thuma, Marc D. Roy, +24

Journal of the American Chemical Society

Molecular BiologyAsialoglycoprotein Receptor LigandsGenome EngineeringCrisprAntisense Therapy +15

Concentration-Dependent Modulation of Amyloid-β in Vivo and in Vitro Using the γ-Secretase Inhibitor, LY-450139

Thomas A. Lanz, Michael J. Karmilowicz, Kathleen M. Wood, +16

Journal of Pharmacology and Experimental Therapeutics

Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor

Carlos Sanhueza, Michael M. Baksh, Benjamin A. Thuma, +21

Journal of the American Chemical Society

Drug TargetMedicinal ChemistryAsialoglycoprotein ReceptorBiochemistryCompact Ligand +17

Pharmacodynamics and Pharmacokinetics of the γ-Secretase Inhibitor PF-3084014

Thomas A. Lanz, Kathleen M. Wood, K. Richter, +16

Journal of Pharmacology and Experimental Therapeutics

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014

Michael A. Brodney, David D. Auperin, Stacey L. Becker, +24

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +8

P3‐380: Dendritic spine density deficits in the hippocampal CA1 region of young Tg2576 mice are ameliorated with the PDE9A inhibitor PF‐04447943

Robin J. Kleiman, Thomas A. Lanz, James E. Finley, +11

Alzheimer s & Dementia

Synaptic TransmissionYoung Tg2576 MiceSynaptic SignalingCsf CgmpCellular Neurobiology +20

Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease

Michael A. Brodney, David D. Auperin, Stacey L. Becker, +23

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAlzheimer's DiseaseBiochemistryMedicineNatural Sciences +9

Development of Fluorophore-Labeled Thailanstatin Antibody-Drug Conjugates for Cellular Trafficking Studies

Chethana Kulkarni, James E. Finley, Andrew J. Bessire, +3

Bioconjugate Chemistry

P2‐375: Efficacy of the novel γ‐secretase inhibitor, PF‐3084014, in reducing Aβ in brain, CSF, and plasma in guinea pigs and Tg2576 mice

Kathleen M. Wood, Thomas A. Lanz, Karen J. Coffman, +8

Alzheimer s & Dementia

Experimental PharmacologySocial SciencesPre-clinical PharmacologyMolecular PharmacologyNeurobiology Of Disease +19