Science · 1993 · 466 citations · 17 references
MedicineImmunologyPathologyAutoimmunityInflammationRheumatologyAutoimmune Disease PathogenesisAutoimmune DiseasesAutoimmune InflammationInflammatory ArthritisJoint DiseaseRheumatoid ArthritisAutoimmune SynovitisCartilage DestructionCollagen-induced ArthritisImmune-mediated ArthritisRheumatoid Arthritis ModelsTissue Infiltration By Inflammatory Cells
The ligand for the CD40 antigen is a 39-kilodalton protein, gp39, expressed on the surface of activated CD4+ T cells and is essential for thymus-dependent humoral immunity. The role of gp39-CD40 interactions in autoimmune disease was investigated in vivo with the use of an antibody that blocks their interactions (anti-gp39). Arthritis induced in mice by immunization with type II collagen was inhibited by anti-gp39. Anti-gp39 blocked the development of joint inflammation, serum antibody titers to collagen, the infiltration of inflammatory cells into the subsynovial tissue, and the erosion of cartilage and bone. Thus, interference with gp39-CD40 interactions may have therapeutic potential in the treatment of autoimmune disease.
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Immunisation against heterologous type II collagen induces arthritis in mice
J. S. COURTENAY, Margaret J. Dallman, A. D. Dayan et al. · Nature · 1980 · 1K citations
Medicine, Immunology, Pathology +11
CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome
R.Cutler Allen, Richard J. Armitage, Mary Ellen Conley et al. · Science · 1993 · 827 citations
Life Sciences, Genetics, Immunology +17