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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Cos1 CellsMolecular PhysiologySignal TransductionBiochemistrySignaling PathwayNatural SciencesMolecular BiologyA Type IiCellular BiochemistryMedicineCell BiologyCell SignalingCellular PhysiologyProtein PhosphorylationAkap-tethered Protein