DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

J. Kirsty Millar, Ben Pickard, Shaun Mackie, +17

Science

Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

Marco Mongillo, Theresa McSorley, Sandrine Evellin, +9

Circulation Research

Cardiac MuscleBiophysical ModelingPde IsoenzymesCellular PhysiologyCamp Response +19

Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2

Graeme B. Bolger, Alexander Peden, Michael R. Steele, +6

Journal of Biological Chemistry

TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid

George S. Baillie, Elaine Huston, Grant Scotland, +10

Journal of Biological Chemistry

Proteinlipid InteractionProtein SecretionBilayer InsertionProtein AssemblyCa2+-triggered Membrane Association +17

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

Elaine Huston, Martin J. Lynch, Ahmed Mohamed, +6

Proceedings of the National Academy of Sciences

GeneticsSignaling SystemDna AnalysisMolecular BiologyCell Death +19

Association with the SRC Family Tyrosyl Kinase LYN Triggers a Conformational Change in the Catalytic Region of Human cAMP-specific Phosphodiesterase HSPDE4A4B

Ian McPhee, Stephen J. Yarwood, Grant Scotland, +5

Journal of Biological Chemistry

Src KinaseProtein FunctionSignal TransductionCatalytic RegionBiochemistry +13

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Angela McCahill, Theresa McSorley, Elaine Huston, +7

Cellular Signalling

Cos1 CellsMolecular PhysiologySignal TransductionBiochemistrySignaling Pathway +10

The Unique Amino-terminal Region of the PDE4D5 cAMP Phosphodiesterase Isoform Confers Preferential Interaction with β-Arrestins

Graeme B. Bolger, Angela McCahill, Elaine Huston, +4

Journal of Biological Chemistry

ImmunologyMolecular BiologyCellular PhysiologyTotal Pde4d ProteinProtein Expression +16

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

Elaine Huston, Simon Lumb, Annette Russell, +7

Biochemical Journal

The Human Cyclic AMP-specific Phosphodiesterase PDE-46 (HSPDE4A4B) Expressed in Transfected COS7 Cells Occurs as Both Particulate and Cytosolic Species That Exhibit Distinct Kinetics of Inhibition by the Antidepressant Rolipram

Elaine Huston, L Pooley, Pascale Julien, +5

Journal of Biological Chemistry