PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

Eric Jaffe, Ralph L. Nachman, Carl G. Becker et al. · Journal of Clinical Investigation · 1973 · 6.9K citations · Full text

Life Sciences, Cell Biology, Physiology +8

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

Johan de Rooij, Fried Zwartkruis, Mark H. G. Verheijen et al. · Nature · 1998 · 2K citations

Life Sciences, Biochemistry, Molecular Biology +8

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

Joe G. N. Garcia, Feng Liu, Alexander D. Verin et al. · Journal of Clinical Investigation · 2001 · 860 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

Jorrit M. Enserink, Anne Elisabeth Christensen, Johan de Rooij et al. · Nature Cell Biology · 2002 · 696 citations

Life Sciences, Cell Biology, Molecular Biology +10

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

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Natural Sciences, Biomedical Engineering, Biophysics +13