Publication | Closed Access
A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening
124
Citations
12
References
2002
Year
Combinatorial ChemistryEngineeringMolecular BiologyCell CultureCytoskeletonEmbryologyMedicinal ChemistryDiversity Oriented SynthesisOrthogonal SynthesisMolecular Biological MethodMorphogenesisEmbryonic DevelopmentPharmacologyTriazine LibraryBiomolecular EngineeringHigh-purity Triazine LibraryDevelopmental BiologySynthetic BiologyZebrafish Embryo ScreeningMedicineDrug Discovery
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
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