Glucocorticoids and acidosis stimulate protein and amino acid catabolism in vivo

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

William E. Mitch, Ruth Medina, S Grieber et al. · Journal of Clinical Investigation · 1994 · 407 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism.

R C May, R A Kelly, William E. Mitch · Journal of Clinical Investigation · 1986 · 371 citations · Full text

Life Sciences, Endocrinology, Physiology +17

Mechanisms for defects in muscle protein metabolism in rats with chronic uremia. Influence of metabolic acidosis.

R C May, R A Kelly, William E. Mitch · Journal of Clinical Investigation · 1987 · 322 citations · Full text

Life Sciences, Biochemistry, Physiology +17

Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles

JB Li, AL Goldberg · American Journal of Physiology-Legacy Content · 1976 · 287 citations

Life Sciences, Nutritional Sciences, Physiology +17

Corticosteroid Feedback Control of ACTH Secretion: Effect of Stress-Induced Corticosterone Secretion on Subsequent Stress Responses in the Rat1

Mary F. Dallman, M. T. Jones · Endocrinology · 1973 · 246 citations

Life Sciences, Endocrinology, Physiology +17