Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study

Modification of Diet in Renal Disease Study Group, Lawrence G. Hunsicker, Sharon G. Adler, +7

Kidney International

ObesityNutritionHemodialysisUrologyRenal Disease +8

The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway.

James L. Bailey, X Wang, Brian K. England, +3

Journal of Clinical Investigation

Muscle ProteolysisProteasomeCrf MusclesOxidative StressRenal Function +20

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

William E. Mitch, Ruth Medina, S Grieber, +5

Journal of Clinical Investigation

Muscle FunctionProteasomeMetabolic RemodelingOxidative StressMetabolic Acidosis Stimulates +18

Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

S. Russ Price, James L. Bailey, X Wang, +5

Journal of Clinical Investigation

Gene TranscriptionInsulin SignalingProteasome ActivityMetabolic SyndromeSkeletal Muscle +20

Effects of dietary protein restriction on the progression of advanced renal disease in the modification of diet in renal disease study

Andrew S. Levey, Sharon G. Adler, Arlene W. Caggiula, +6

American Journal of Kidney Diseases

NutritionUrologyRenal DiseaseRenal FunctionMedicine +8

Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle

S. Russ Price, Brian K. England, James L. Bailey, +2

American Journal of Physiology-Cell Physiology

Rat MuscleMuscle FunctionProteasome MrnasTotal RnaCytoskeleton +18

Glucocorticoids and acidosis stimulate protein and amino acid catabolism in vivo

R C May, James L. Bailey, William E. Mitch, +2

Kidney International

BiochemistryMedicinePhysiologyCatabolismAcidosis Stimulate Protein +5

Abnormalities in protein synthesis and degradation induced by extracellular pH in BC3H1 myocytes

Brian K. England, Jane L. Chastain, William E. Mitch

American Journal of Physiology-Cell Physiology

Rat MuscleProtein TurnoverMolecular BiologyCellular PhysiologyInsulin Signaling +23

Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC3H1 myocytes require an interaction between glucocorticoids and acidification.

U Isozaki, William E. Mitch, Brian K. England, +1

Proceedings of the National Academy of Sciences

Molecular RegulationProteasomeGlucocorticoidOxidative StressMetabolic Acidosis Stimulates +21

Chronic metabolic acidosis accelerates whole body proteolysis and oxidation in awake rats

R C May, Tahsin Masud, Brian A. Logue, +2

Kidney International

Metabolic SyndromeAwake RatsEnergy MetabolismMetabolic DisorderBiochemistry +11