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Structure–activity relationship studies of flavopiridol analogues

Krishna K. Murthi, Marja Dubay, Christopher McClure, Leonardo Brizuela, Michael D. Boisclair, Peter J. Worland, Muzammil M. Mansuri, Kollol Pal

Bioorganic & Medicinal Chemistry Letters · 2000 · 54 citations · 10 references

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10

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Manuel Serrano, Gregory J. Hannon, David Beach · Nature · 1993 · 3.7K citations

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

Walter Filgueira de Azevedo, H J Mueller-Dieckmann, Ursula Schulze‐Gahmen et al. · Proceedings of the National Academy of Sciences · 1996 · 500 citations · Full text

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Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

Adrian M. Senderowicz, Donna Headlee, Sherman F. Stinson et al. · Journal of Clinical Oncology · 1998 · 408 citations

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Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-8275

Gurmeet Kaur, M Stetler-Stevenson, S Sebers et al. · JNCI Journal of the National Cancer Institute · 1992 · 351 citations

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Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275

Michael D. Losiewicz, B. A. Carlson, Gurmeet Kaur et al. · Biochemical and Biophysical Research Communications · 1994 · 346 citations

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