Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. III: Sensitivity of human cell types to known genotoxic agents

Ascorbate is an outstanding antioxidant in human blood plasma.

Balz Frei, Laura England, B N Ames · Proceedings of the National Academy of Sciences · 1989 · 1.9K citations · Full text

Life Sciences, Biochemistry, Biochemical Pharmacology +16

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens

David Kirkland, Marilyn J. Aardema, L.M. Henderson et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2005 · 752 citations

Pharmacy, Toxicology, Genetic Toxicology +9

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

David Kirkland, Stefan Pfuhler, David Tweats et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2007 · 437 citations

Pharmacy, Toxicology, Good Laboratory Practice +12

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

Paul Fowler, Katie Smith, Jamie Young et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2011 · 225 citations

Pharmacy, Cell Biology, Toxicology +14

Use of human hepatoma cells for <i>in vitro</i> metabolic activation of chemical mutagens/carcinogens

A.T. Natarajan, F. Darroudi · Mutagenesis · 1991 · 185 citations

Pharmacy, Toxicology, Carcinogenesis +15